Aging heart can be prevented, say scientists

According to Scientists in Japan, they have discovered evidence showing the possibility to delay or avert heart failure in humans. As per a paper published in the journal Circulation a leading researcher and assistant professor of medicine at Kyoto University Graduate School of Medicine - Tetsuo Shioi and his team explains how they have successfully dealt with the process of restraining a P13K gene variety in a group of elderly mice. These genes are responsible for regulating the endurance of cells and the aging of tissues. According to their previous studies, the inhibition of these genes helps in extending the lifespan of the roundworm, thereby maintaining the hearts of old fruit flies healthy. According to their studies on mice, when these genes were left unharmed, the mice with the suppressed genes was offered with enhanced cardiac function and less fibrosis which is responsible for making the heart inflexible. This was also successful in reducing the biological markers of aging. Tetsuo Shioi remarked that as per their study it is revealed that the process of natural aging of the heart can be prevented considerably by amending the functions of insulin, which thereby helps in preventing age-related vulnerability to heart failures. Another chief risk factor for heart failure is old age. According to the World Health Organization, old age brings about a condition when the heart strains to pump sufficient blood to other parts of the body, thereby limiting the supply of adequate amount of oxygen that the body needs. As per the reports provided by the American Heart Association, around 5.7 million Americans suffer from heart failure and almost 10 out of every 1,000 people that exceed 65 years of age are at high risk of heart failure annually. According to the professor of medicine at the University Of Pennsylvania School Of Medicine in Philadelphia, Mr. Mariell Jessup elderly people suffer from a gradual loss of heart cells and are at high risk of various types of cellular deformities that turn their remaining cells contract less powerfully. According to Shioi their early work in a mouse model offers a solid clarification of role of PI3K gene in the aging of the heart. He also added that this clarification will enable other scientists to understand if the human hearts are influenced in the same way. Like mammals, mice are also considered the best substitute for studies of human diseases and conditions that involve their physiology, body plan, genome share and many other similar features.